Liposomes microscopic, fluid-filled pouch whose walls are made of layers of phospholipids identical to the phospholipids that make up cell membranes. Liposomes are used to deliver certain actives to the skin. Liposomes are sometimes used in cosmetics. Because they act as vehicles for the delivery of both water- and of oil-soluble materials to the cell
Liposomes were first produced in England in 1961 by Alec D. Bangham, who was studying phospholipids and blood clotting. It was found that phospholipids combined with water immediately formed a sphere because one end of each molecule is water soluble, while the opposite end is water insoluble. Water-soluble medications added to the water were trapped inside the aggregation of the hydrophobic ends; fat-soluble medications were incorporated into the phospholipid layer.
When cosmetics containing liposomes are applied to the skin, for example, the liposomes are deposited on the skin and begin to merge with the cellular membranes. In the process, the liposomes release their payload of active materials into the cells. As a consequence, not only is delivery of the actives very specific--directly into the intended cells.
Depend upon the structure there are two types of liposomes;
unilamella liposomes; Unilamellar vesicle has a single phospholipid bilayer sphere enclosing aqueous solution.
Multiple layered or Multilamella liposomes; multilamellar vesicles have onion structure. Typically several unilamellar vesicles will form on inside the other in diminishing size, creating a multilamella structure of concentric phospholipid spheres separated by layers of water. Hydrophilic actives are contained within the liposomes and hydrophobic actives are trapped between bilayers.
Multiple layered liposomes have advantages to general one-layer liposomes: This enables multiple layered liposomes to encapsulate large amounts of both hydrophilic and hydrophobic active ingredients. T he multiplicity of coats also increases the effect of a reservoir and makes extremely prolonged releases of actives possible. Also liposomes are very safe and could not any irritate in skin because of their main component is the identical. This liposome formula can use for finished products which have to the best formula for health of human.